Platelet-derived growth factor receptor-α: a novel therapeutic target in human hepatocellular cancer
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منابع مشابه
Platelet-derived growth factor receptor-A: a novel therapeutic target in human hepatocellular cancer
Hepatocellular cancer (HCC) is a disease of poor prognosis. Identifying novel molecular aberrations might present opportunities to identify new therapeutic targets. Due to the similarities between the processes of development and cancer, we used early developing livers to identify genes that might play a primary role in HCC. Plateletderived growth factor receptor-A (PDGFRA) was identified from ...
متن کاملPlatelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer.
Hepatocellular cancer (HCC) is a disease of poor prognosis. Identifying novel molecular aberrations might present opportunities to identify new therapeutic targets. Due to the similarities between the processes of development and cancer, we used early developing livers to identify genes that might play a primary role in HCC. Platelet-derived growth factor receptor-alpha (PDGFRalpha) was identif...
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Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFR...
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INTRODUCTION STI571 is a tyrosine kinase inhibitor, which was found as a specific inhibitor of BCR/ABL, the major causative tyrosine kinase of chronic myelogenous leukemia (CML). However, it was also a powerful and selective inhibitor of platelet-derived growth factor receptor (PDGF-R) and c-Kit. Based on encouraging preclinical results, STI571 was approved by the Food and Drug Administration i...
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PURPOSE Platelet-derived growth factor receptor α (PDGFRα) expression is frequently observed in many kinds of cancer and is a candidate for therapeutic targeting. This preclinical study evaluated the biologic significance of PDGFRα and PDGFRα blockade (using a fully humanized monoclonal antibody, 3G3) in uterine cancer. EXPERIMENTAL DESIGN Expression of PDGFRα was examined in uterine cancer c...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2007
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-06-0720